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KMID : 0438219750120010251
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Korea University Medical Journal
1975 Volume.12 No. 1 p.251 ~ p.262
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A Study on the Relationship between Birthweight, Gestational Period and the Lecithin Sphingomyelin Ratios of Amniotic Fluid
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Abstract
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A total of forty five amniotic fluids obtained from Korean pregnant women during their labours and the forty five newborn infnats, including 14 cases of low-birth-weight-infants and 31 cases of normal-birth-weight-infants were studied.
The lecithin sphingomyelin ratios of the amniotic fluid were measured by the thin-layer chromatography. the phosphorus content of sphingomyelin and lecithin spots were determined and thereby the ratios were calculated. The L/S ratios of amniotic fluid of fetuses and the clinical signs of the newborns were observed and compared with the relationship between birthweight and gestational period.
The rasults were as follows:
1. The L/S ratios of amniotic fluid of fetuses apparently increased since 38 weeks of gestational period and continued to the near term. The L/S ratios of 42 to 44 weeks of gestational age tend to be decreasing than those of the term. (Fig. I )
2. The L/S ratios showed large variations with gestational period but there was more significant linear relationship with the duration of gestation than the birth weight.
3. The L/S ratios of amniotic fluid increased with the birth weight but showed a tendency to decrease in cases of over 3700 gm of birth weight.
4. The L/S ratios of 14 cases of low-birth-weight-infants appeared from 0.4 to 3.2 (Table 1). 3 premature infnats of them expired after birth and their L/S ratios revealed 0.4,-- 0.43 and 0.83 respectively. Ten cases of low-birth-weight-infants did not show the respiratory distress syndrome in spite of their L/S ratios less than 2.0.
5. The L/S ratios of 31 cases of normal-birth-weight infants appeared in the ratios of 1.34 to 5.33, six cases of which in less than 2.0 of L/S ratio, all these infants were in fair clinical condition. (Table j )
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